GPR39 is a gene located on chromosome 2q21-q22. It encodes a protein that belongs to the ghrelin receptor family of rhodopsin-type G-protein-coupled receptors (GPCRs). GPCRs are a large and ancient family of proteins that sit on the cell surface, acting as the cell's "gatekeepers." They detect molecules outside the cell and activate internal signal transduction pathways and cellular responses.
The most compelling research surrounding concerns its relationship with adipose tissue dysfunction . GRET-39
In this post (codenamed for our internal series), we are stripping away the complex apps and fancy gadgets. Here are the five fundamental pillars to stop planning and start executing. GPR39 is a gene located on chromosome 2q21-q22
Thus, the intermittent, brief elevation of GRET-39 seen in active individuals is adaptive. The chronic, baseline elevation seen in sedentary, obese individuals is maladaptive. This is analogous to cortisol: acute spikes help us handle stress, but chronic elevation leads to Cushing's syndrome. Thus, the intermittent, brief elevation of GRET-39 seen