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The ZNF384 protein is especially significant in cancer research. Chromosomal rearrangements, or fusions, involving the ZNF384 gene are a known cause of certain types of acute leukemia, including B-cell acute lymphoblastic leukemia (B-ALL). When the ZNF384 gene fuses with another gene (e.g., EP300, TAF15, or CREBBP), it creates a fusion protein that can disrupt normal gene regulation, driving uncontrolled cell growth and leading to leukemia. hmn384
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