Automatic or 16x (Minimal performance impact on modern GPUs).
These settings are based on community stability reports for Madden 12 and similar titles like Madden 11. PPU Decoder: Recompiler (LLVM) SPU Decoder: Recompiler (LLVM) madden 12 rpcs3 settings
Vulkan (Do not use OpenGL; it causes massive performance drops). Automatic or 16x (Minimal performance impact on modern GPUs)
For a more tailored experience, you can dive into the emulator's advanced settings. madden 12 rpcs3 settings