Siberian-mouse-hd-154-msh2-003

The MSH2-003 strain is particularly interesting due to its involvement in studying DNA mismatch repair (MMR) mechanisms. The MSH2 gene is a key component of the DNA mismatch repair system, which corrects errors in DNA replication and recombination. Mutations in MSH2 have been associated with hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome.

While the Siberian Mouse HD-154 (MSH2-003) model holds tremendous promise, there are challenges to be addressed. These include: siberian-mouse-hd-154-msh2-003